Situation: After the client fixed Windows 10 update issue, he has a problem to run office word with this error “C:\Windows\SYSTEM32\dxgi,dll is either not designed to run on Windows or it contains an error.” status 0xc0000020.
Resolution 1: Repairing Office online
Go to Settings > Apps > Apps and Features > Microsoft Office > Modify > Repair.
Resolution 2: Repair corrupted system files.
Check for system file corruption: Open Command Prompt as an administrator and run the command “sfc /scannow” to check for and repair any corrupted system files.
Resolution 3: Re-install Microsoft Visual C++
Go to Settings > Apps & Features. uninstall Microsoft Visual C++, restart PC.
Download and install the latest Microsoft Visual C++ from here: https://www.microsoft.com/en-us/download/detail…
Resolution 4: Re-install office 365.
Resolution 5: Run System restore. please refer to this post: