Q: I have a new Windows 10 computer. My DYMO LableWroter 450 doesn’t work. Or sometimes works. What could be the problem:
chicagotech.net: We are assuming the new computer comes with USB v3 and V2. Please try to connect the USB cable to USB v2. That fixes most problems.
Also check this statement from Dymo:
Setting up your DYMO 450 Turbo label printer for Windows PC – How can we help?
Important: Some Dymo Label Printers manufactured after April 2014 will require an update from Dymo to work with USB 3.0 ports. To learn more about this click the link here.